Autoantibodies to endothelial cells and neutrophil cytoplasmic antigens in systemic vasculitis
نویسندگان
چکیده
منابع مشابه
Anti-neutrophil cytoplasmic autoantibodies: methodological aspects and clinical significance in systemic vasculitis.
Antineutrophil cytoplasmic antibodies (ANCA) are the serological hallmark of some idiopathic systemic vasculitides, such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and, to a lesser extent, Churg-Strauss syndrome (CCS), the so-called ANCA-associated vasculitides (AAV). ANCA were first detected by immunofluorescence (IIFT), subsequently the target antigens myelopero...
متن کاملSerum soluble interleukin 2 receptor levels in anti-neutrophil cytoplasmic autoantibodies--positive systemic vasculitis.
Systemic vasculitis is characterized by the presence of autoantibodies to neutrophil cytoplasmic antigens (ANCA). The role of T-lymphocytes in systemic vasculitis remains uncertain. In the present study, we attempted to explore the role of T-lymphocytes in systemic vasculitis by measuring the serum soluble interleukin 2 receptor (sIL2R) levels in seven vasculitic patients and comparing the sequ...
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Systemic vasculitis is a heterogeneous group of disorders characterized by inflammation andnecrosis in the vessel wall. The diagnosis of a systemic vasculitis is challenging, because patients usually present a broad spectrum of manifestations that vary according to the predominant size of vessels affected, organs and systems involved, and the extent of the inflammatory process (1). In systemic ...
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anti-neutrophil cytoplasmic autoantibodies have been detected in patients with some autoimmune and vascular diseases such as wegner's granulomatosis, polyarthritis nodosa and systemic lupus erythematosus. indirect immunofluorescence technique has been employed to detect these autoantibodies. by this method, two general patterns of antineutrophil cytoplasmic antibodies were seen: a cytoplasmic (...
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We report five cases of Wegener's granulomatosis all of whom had clinical and histological evidence of disease activity at presentation and in whom autoantibodies to neutrophil antigens were detected. This test may prove useful for the diagnosis of this serious condition and help to monitor disease activity during treatment.
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1990.tb05431.x